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Nature has provided us with a potent remedy for a wide range of afflictions in wild oregano herb and oil. An age old remedy, Oil of Oregano, has been scientifically researched and proven to be one of the strongest and most effective broad spectrum antibiotics known to man. It is natural and safe to use. It will not create more mutant strains of bacteria. It effectively kills bacteria of every variety using only tiny amounts.5,7-dihydroxy-3,4-dimethoxyflavone and regiolone showed the best pharmaco-toxicological profile, since they promoted cell death in the two cancer cell lines (IC50 ranging between to μM) (Table 1), but were almost inactive on the normal cells treated with IC50 equivalent concentrations of each compound [169]. Its important to remember that while high dose oregano oil works as an antimicrobial, there hasnt been much clinical research done. Animal research, usually done in mice, has shown that oregano oil is effective. Currently, it is not clear if oregano oil spares normal gut bacteria or nothowever, eating foods that encourage healthy gut bacteria (yogurt, fermented foods) can usually help support the re-population of healthy gut bacteria. Former Shaman Pharmaceuticals scientists Moran et al. [100] discuss the irony in the situations described above, indicating that the majority of the biotech industry is not involved in bioprospecting, since most companies favor the use of cheaper and faster synthetic technologies over the complex process involved in exploring for natural products.
Even if cancer represents a burden for human society, an exhaustive cure has not been discovered yet. Low therapeutic index and resistance to pharmacotherapy are two of the major limits of antitumour treatments. Natural products represent an excellent library of bioactive molecules. Thus, tapping into the natural world may prove useful in identifying new therapeutic options with favourable pharmaco-toxicological profiles. Juglans regia, or common walnut, is a very resilient tree that has inhabited our planet for thousands of years. Many studies correlate walnut consumption to beneficial effects towards several chronic diseases, such as cancer, mainly due to the bioactive molecules stored in different parts of the plant. Among others, polyphenols, quinones, proteins, and essential fatty acids contribute to its pharmacologic activity. The present review aims to offer a comprehensive perspective about the antitumour potential of the most promising compounds stored in this plant, such as juglanin, juglone, and the ellagitannin-metabolites urolithins or deriving from walnut dietary intake. All molecules and a chronic intake of the fruit provide tangible anticancer effects. However, the scarcity of studies on humans does not allow results to be conclusive.
In most cases, vendors mentioned species as rare because they themselves did not sell them; in many cases, these plants were very common outside the market (e. g. , Plantago major or common plantain) or because demand was so low, that it would not have made sense to carry them in their inventories. Very small vendors had inventories that represented the most common medicinal plants available and excluded most species in the large witchcraft segment of the pharmacopoeia. On the other hand, well-established large stands specialized in supplies for healers (including magical plants). Complementing the positive examples from the UN University-Yokohama report is the lesson learned from a failed project in Northern India which sought to develop a medicinal plant value chain between local Himalayan farmers and a Dutch company (Ayurveda Health) in a project undertaken by The Royal Tropical Institute (KIT) and the Center for Sustainable Development (CSD) of The Netherlands in cooperation with local government agencies [120].
Psychosomatic disorders were the most outstanding afflictions treated with traditional herbal mixtures, with almost 30 of all recipes applied, followed by respiratory illnesses, female issues, kidney problems, and heart problems. Susto (fright), problems of the nervous system, general systemic inflammation, and bronchitis together accounted for almost 25 of all remedies used. In many cases, healers used only one or two common mixtures to treat an illness. This degree of consensus between different healers shows great sophistication in the diagnosis and treatment of specific disorders. On the contrary, when it came to the treatment of unspecific disease categories like inflammation or bronchitis, every healer seemed to use her/his own specific mixture to treat the problem. This was particularly obvious in the treatment of neurological and psychosomatic problems, for which the majority of plants and mixtures were employed.
- The first was a control group that wasnt given colitis.
- The second was given colitis, but no essential oils.
- Groups 3, 4, and 5 were fed oregano and thyme oil in varying concentrations, all of which were 0.5 or below.
Plants used for kidney inflammation had a much lower efficacy against bacteria and fell within the range of species that are traditionally used to treat other bodily disorders. Only species used for spiritual/ritual treatments scored worse. Of these, only 22 showed some antibacterial activity. However, amongst the spiritual plants, 38 of the species used for cleansing baths did in fact show activity, while only 15 of the plants often used in protective amulets (mostly species with the families of Lycopodiaceae and Valerianaceae) showed limited antibacterial activity. To comprehensively examine the interesting pharmacological profile of Uros on colon cancer cells, we include some studies reporting its ability to sensitise cancer cells to traditional anticancer drugs, and to selectively target cancer cells.
Precedents for this study have been established by early colonial period chroniclers [1518]; the plant collections (293 plants in crates 11 and 12 of 24) of Bishop Baltasar Jaime Martínez Compañón sent to the Palacio Real de Madrid along with cultural materials in 1789 under the title Trujillo del Perú in 9 illustrated volumes [1921]; the travel journals of H. Ruiz from 1777 to 1788 [22]; the work of Italian naturalist Antonio Raimondi [23]; ethnoarchaeological analysis of the psychedelic San Pedro cactus [24]; curandera depictions in Moche ceramics [25], and research on the medicinal plants of Southern Ecuador [2629]. This is because natural products like oregano oil are usually gentler than prescription drugs and are presumed to do less damage to the healthy gut bacteriathe microbiome. The fact that oregano oil has been shown to be just as effective as regular antibiotics in many cases is a very positive finding. The kinder and gentler mechanism of action of oregano oil means that there is a decreasedrisk of adverse effects that are often seen with prescribed antibiotics. Nowadays, natural compounds play a crucial role in anticancer therapy, either as whole or single molecule.
While there is limited medical research on oregano oil, we know from traditional use that it is a very potent natural antibiotic. While taking normal amounts of oil of oregano for short durations is not considered dangerous, overdosing can lead to problems. It is also generally not recommended to take oil of oregano every day unless using it under the care of a medical practitioner. Carvacrol pokes holes in the cell membranes of bacteria and causes the leakage of essential minerals and can alter the internal pH of the bacterial cell. Carvacrol is also thought to do less damage to the overall microbiome compared to conventional antibiotics, making it a crucial ingredient in oregano oils ability to be a beneficial natural antibiotic. In addition to its antibacterial activity, carvacrol is also effective against yeast (Candida) and some viruses. While it was very easy for all vendors to name their most important and frequently sold species, it proofed impossible to get detailed information about species that vendors observed as rare or disappearing.
Furthermore, they usually require only low-cost manufacturing procedures, and are very easy to process and modify in order to ameliorate both stability and biological activity [159]. After extraction, walnut-derived proteins have to be physiologically or artificially digested, generating the bio-functional peptides. Bioactive peptides need to be released after enzymatic hydrolysis [160,161]. Clearly, from the same protein source, different enzymes or different hydrolytic conditions, such as temperature, the enzyme-substrate ratio, or length of procedure, produce peptides of different quality and displaying different bioactivities [116]. For the first time, in 2015, a bio-peptide from walnut residual proteins showed marked anticancer potential. Since then, three promising peptide sequences have been identified. A peptide fraction obtained from chymotrypsin hydrolysis of the protein residue of walnut inhibited the survival of breast and colon cancer cells (MDA-MB231 and HT-29), an effect associated with its antioxidant activity [118].
Of note, looking at a possible clinical translation, juglone showed even better cytotoxic activity than tamoxifen, the gold standard drug for ER+ breast cancer therapy, on MCF-7 cells [93]. However, a crucial issue that impedes the elaboration of an exhaustive picture of the antitumour potential of Juglans regia is the scarcity of clinical studies. To our knowledge, the only works that linked cancer therapy and walnut intake are summarised here, and both suggest that 6 months of chronic intake is unable to reduce the expression of cancer biomarkers. Certainly, further studies are needed to draw convincing conclusions about walnut activity on humans. Kidney and urinary tract diseases are a major health challenge worldwide. Many plant species are traditionally used for kidney disease treatment, and some have been investigated for their efficacy with positive results. An often-limiting factor to these investigations is lack of comprehensive ethnobotanical data to help choose plant candidates for potency/efficacy tests. Since the plant parts utilized in preparation of kidney remedies are reported in this survey, it serves as an indication of species that may need further ecological assessment on their regeneration status.
The authors point out that worldwide medicinal plants are being depleted at a rapid pace due to large-scale, unsustainable collection from natural habitats. Conservation of these species is critical for four reasons: (1) they are a source of natural ingredients used by the manufacturers of modern pharmaceuticals resulting in a large and increasing demand [121123]; (2) medicinal plants form the basis of homeopathy and traditional medicines, and, along with traditional knowledge, are crucial for traditional healers, who play a vital role in the lives of poor people and their animals in developing countries [2]; (3) the collection and marketing of medicinal plants are a valuable source of livelihood for large numbers of poor people in developing countries; and (4) medicinal plants are an essential component of biological diversity and conservation. As more research about this natural antibiotic option comes to light, it is likely that we will see more and more how oregano oil is a great alternative to pharmaceutical antibiotics.
Epidemiologic studies showed that a plant-enriched diet lowers the risk of many chronic diseases, including cancer [198]. For its part, Juglans regia, better known as common walnut, demonstrated interesting antitumour potential on different cell lines and animal models. Both single molecules stored in different parts of the plant and fully-fledged extracts exhibited interesting anticancer potential. The present review outlined the phytochemical composition of walnut and its resulting antitumour potential. Walnut is a container of very active molecules, such as EAs, quinones, and fatty acids. The compounds discussed in this review owe their potential antitumour activity to different mechanisms, which can be summarised as cell-cycle arrest, apoptosis induction, and metastatisation inhibition. Many molecular mechanisms are involved in this phenomenon. Uro-A, juglone, juglanin, and walnut-extracted peptides exhibit unquestionable antitumour activity on different in vitro tumour types confirmed by in vivo studies.
The anticancer effect was not correlated with the total phenolic content in the extracts, since seeds were shown to be the most enriched in those antioxidants [120]. Other different extracts of walnut leaves have been examined for their anticancer potential on oral squamous (BHY), breast (MCF-7), and colorectal (HT-29) carcinomas. Protic and aprotic solvents with different polarities were used to prepare the mixtures (methanol, ethyl acetate, chloroform, and hexane). The most active turned out to be the chloroform one [122]. Cell-cycle arrest in the G0/G1 phase and apoptosis were responsible for the observed proliferation inhibition [122]. Furthermore, the same extract was characterised, and 5-hydroxy-3,7,4-trimethoxyflavone, lupeol, daucosterol, 4-hydroxy-a-tetralone, β-sitosterol, 5,7-dihydroxy-3,4-dimethoxyflavone, and regiolone were identified but not quantified. They were tested singularly on MCF-7 and BHY cancer cell lines and on normal mouse embryonic fibroblasts (NIH-3T3).
Nonetheless, biotechnology spawns ethical, social, and legal debates at the margins of pharmaceutical bioprospecting, including the collaboration between big business and big science, the ethics of genetic engineering, and the patentability of life forms as well as ideas about genetics and racism, culture, and ethnicity. However, it is significant to note that, since the inauguration of the CBD, no pharmaceutical bioprospecting product developed by using traditional knowledge has generated an economic profit. (But this does not mean that pharmaceutical companies do not try to impede or coopt efforts to get natural plant products to market. ) Also, only a small number of bioprospecting research expeditions begin by using ethnobotany as a discovery methodology, with the work soon evolving into economic botany as the laboratory focus shifts to the plants chemistry, biological activity, and pharmacology/toxicology. During drug discovery, active chemical components are isolated, often modified, and patented. Patented information then becomes a commodity in itself. India provides a positive example of the proactive application of this approach.
At 20 and 40 μM, Uro-A increased sensitivity of Caco-2, SW480, and, to a lesser extent, HT-29 cells to 5-fluorouracile (5FU) and its metabolite 5-deoxy-5-fluorouridine, which translated in a decreased 50 inhibitory concentration (IC50) of those drugs, in a significant accumulation of cells in S and G2/M phases caused by the accumulation of cyclin B1 and A, and in a slight activation of the apoptotic machinery [66]. Uro-A exhibited a remarkable safety profile against normal cells. Mixtures and single Uros showed a less marked effect on the non-transformed cell line CCD18-Co than that recorded on tumour cells, suggesting a selectivity of action towards cancer cells [52]. For example, Doterra says how to use it in food is to add just one drop, for things such as spaghetti sauce. When not eating it and using it as a supplement, the dosage they claim to maintain healthy immune function is still one drop daily. If undiluted, wild oregano oil under the tongue can burn, so even that single drop should be mixed with an edible carrier oil like coconut, or diluted in 4 ounces of water for drinking. Uses in mouthwash for bad breath is another idea for dilution.
Taking advantage of the novelty criterion in international patent law, with regard to the documentation of Ayurvedic and other traditional medicine, millennial Sanskrit texts as well as modern publications are included in a traditional knowledge database, which is subsequently provided to patent agencies. The expectation is that, by placing the knowledge about long-term cultural precedents for traditional uses in the public domain, this research will prove that contemporary patent applications derived from local medicinal knowledge lack originality that is that they are not novel enough to qualify as inventions warranting protection under international patent law and are thus not patentable. Healers in Northern Peru often employ very sophisticated mixtures of a variety of plants in their treatments. The use of single species for treatments was rare. Most commonly, plant material was boiled in water, or in some cases in sugarcane alcohol (aguardiente) to extract the active compounds. In some cases, plant material was macerated in cane alcohol or wine for longer periods of time before use. Since theres limited human clinical data, most of the adverse reactions are based off the aforementioned animal studies, as well as product reviews of what people report.
The long term use of oregano oil is not recommended, as most dietary supplements list a time period of up to several weeks. Its not safe for babies, toddlers, or children. Among the natural antioxidants, oregano oil is one of the most powerful. It protects cells from free radical damage in the same way it prolongs the shelf life of foods. Take a few drops daily under the tongue to slow the effects of aging and maintain healthy cell structure. First of all, anytime you can get the same beneficial effects with a natural product like oregano oil compared to using a pharmaceutical product, it is most often well worth using it. [11] Leyva-López N, Gutiérrez-Grijalva EP, Vazquez-Olivo G, et al. Essential oils of oregano: biological activity beyond their antimicrobial properties. Molecules. 2017;22(6):989. The investigation of plant mixtures used in traditional medicine in Northern Peru yielded a total of 974 herbal preparations used to treat 164 different afflictions [127]. The classification of diseases followed the curanderos terminology. To allow a better overview, the different disease concepts were grouped in more inclusive disease categories, according to their similarity.
Thus, their use is conceived to increase the efficacy of traditional anticancer agents, and at the same time, to decrease their toxicity. Indeed, the combination of botanical and traditional agents would potentially decrease the dose of a given traditional drug that is necessary to reach the therapeutic effect, hence limiting its harmfulness [16]. The community-based approach shows allegiance to the Alma Ata primary health care model. Examples include the barefoot doctors strategy in China and the social health activist programs in India. Given the centrality of biodiversity in human lives, there is still a need to develop sustainable strategies for health maintenance combined with conservation of biological resources linked to local knowledge and practices. This is relevant even in developed countries where there is an increasing demand for alternative and complementary medicine. Natural products have a diversified composition comprising active molecules that will translate into a multi-target way of action. Indeed, phytochemicals stored in the plant can act in a synergistic way to concur a final biological effect.
If it is still too strong for you, add more carrier oil until it suits your needs. In order to standardize Oregano oil, something has to be added or taken away. Carvacrol has been chosen as the ingredient to standardize. Carvacrol levels are increased by adding Carvacrol to the water during distillation or afterwards to the oil or by fractionating the essential oil after distillation by boiling off other natural components of the oil to make the Carvacrol percentage higher in relation to what is left. In both cases the natural synergy of active constituents in the oil is put out of balance without any thought of the effect that will have on the healing properties of the end product. In fractionation, whole parts of the Oregano plants makeup are removed in ignorance of their function! What this means is that a standardized oil of oregano offers a high level of key active compounds to support the immune systems efforts in tracking down and eliminating pathogens (including the rhinovirus responsible for the common cold).
Often, however, legitimate economic considerations also play a role in the defensive reactions of these societies to the well-intended but naïve desire of the academic world to place its findings in the public domain. Greaves et al. [113, 114] have warned that the downside in this approach is that a colonializing archive can become easily mined for clues in the search for new drugs without the inconvenience of fieldwork or inclusion of source communities in the benefits derived from products resulting from research. Due to their fat, protein, vitamin, and mineral content, walnut kernels are a very healthy source of nutrients. For many years, they have been employed for their perfect balance of ω-3 and ω-6 PUFAs [23]. Oils are extracted by discarding the derived residue. In part to avoid waste, but also due to the new knowledge about the anticancer potential of food-derived peptides, the residues have, in recent years, started to be used for protein extraction [116]. A large amount of evidence revealed that peptides might play a role as therapeutic agents. Indeed, some peptide sequences showed interesting antitumour potential together with minimal adverse immunogenicity and exceptional tissue permeability.
, Gentianella spp. , and Valeriana spp. , or are prone to toxic side effects like Ephedra americana and Brugmansia spp. I think that this is very important to explain to readers clearly, because when something has a blanket warning that its not to be used in pregnancy, that could be for all sorts of reasons, and some people may go ahead and ignore that admonition even if the action might have a chance to harm the developing fetus (like drinking alcohol, smoking, using hair dye, taking anti-depressants, or whatever) but taking even a little bit of oregano oil for a few days might directly END a pregnancy, and it has done this in historical cases, so therefore its a very serious substance that should be treated with a lot of caution, especially by women of reproductive age if there is any chance that they might be pregnant or might soon become pregnant. Probably the major concern in many traditional communities is that their spiritual legacies will be profaned by a secularized and consumer-driven outside world.
Among many diseases, the intrinsic nature of natural products and botanical drugs perfectly fits the complexity of cancer pathology. Cancer is still a major burden all over the world. Although many anticancer agents have been identified, toxic effects and resistance impose as huge limits on their use [14]. Indeed, in the majority of cases, the side effects of traditional drugs hamper clinical outcomes. Thus, the need for new agents characterised by better pharmaco-toxicological profiles is compelling. For a long time, reductionist approaches using isolated molecules dominated in cancer drug discovery [15]. However, an understanding of the therapeutic potential of botanical-drugs opened the way to explore the synergistic or additive effects that arise from the mixtures of compounds occurring in plants [15]. Furthermore, natural products are usually characterized by a better toxicological profile compared to traditional drugs.
The Top 10 Nutrition Tips for Weight Management and Metabolic Health
At the same time, no toxicity was registered on the non-transformed HUVEC cells treated with the same fraction [118]. A so-called pepsin-colorase pp and a pepsin-neutrase hydrolysate showed cytotoxic activity on breast cancer cells (UACC-62), while not exerting any biological activity on a panel of cells including MCF-7, HT-29, and U251 [117]. As expected, the starting non-hydrolyzed proteins did not exert any antitumour effect [117]. So far, the most characterised peptide is the sequence CTLEW (Cys-Thr-Leu-Glu-Trp) (Figure 1), obtained through a papain enzyme reaction of walnut protein residue. Its amphiphilic structure, and the resulting stabilisation achieved thanks to the di-sulfur bonds between the side C and W, make it very suitable for crossing cell membranes. CTLEW promoted apoptosis and autophagy on MCF-7 and cell-cycle arrest on Caco-2 and HeLa cells, but did not exert any toxic effect on the non-transformed IEC-6 cells, nor on spleen lymphocytes [116]. No less important, Ma et al. demonstrated that CTLEW possesses immunomodulatory potential.
Mal Aire (Bad Air), Mal Viento (Bad Wnd), Susto or Espanto (Fright), Mal Ojo (Evil Eye), and Daño or Brujería (Sorcery) are seen as very common illnesses in Andean society. Causes include sudden changes in body temperature (Mal Aire, Mal Viento), any kind of shock (Susto, Espanto), humors or spells cast by other people (Mal Ojo), poisoned food, and curses. (Daño, Brujeria). Medical problems caused by outside influences were reported in a wide variety of studies [70, 163]. The Western concept of psychosomatic disorders comes closest to characterizing these illnesses. Many remedies used for spiritual healing and other noninfection purposes did show antibacterial efficacy in vitro but were not listed as such by the local healers. This might be explained by the fact that they either are very inconsistent in their activity (e. g. , Mandevilla trianae, Loricaria spp. , Lonicera japonica, Hypericum laricifolium, Hyptis sidifolia, Mentha piperita, Brachyotum naudinii, and Cydonia oblonga) or are so closely related that identification, especially when dried, can be a problem, for example, in the case of Baccharis spp.
(3) Encourage debate, exchange, and coordination between people and institutions working in the field of Natural-Popular Medicine. (4) Rescue Andean and Andeanized foods to improve food consumption. Home remedy websites talk of using an oregano oil dosage highly diluted in water for the prevention or treatment of UTI. Trying to get rid of the infection without going to the doctor may sound appealing, but that advice has never been scientifically studied. It could be risky to self-treat because even a relatively mild UTI can turn into something much worse. Among Juglans regia seeds, green husk, and leaves, the latter seem to carry the highest antitumour potential [120]. Methanol extracts of these parts obtained with the same procedures were tested on human renal epithelial cells (A498 and 769-P) and colorectal cells (Caco-2). Seed extracts did not exert any effect on 769-P nor Caco-2 cells, and green husk failed only on Caco-2 cells, while leaf extract promoted cancer cell death on all tested cell lines and with the lowest IC50 (Table 1).
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Although not formally acknowledged, Southern Ecuador falls into the Northern Peruvian cultural area. It appears to represent a region where traditional plant knowledge, though important, has declined considerably. Southern Ecuadorian curanderos and parteras (midwives) have almost entirely abandoned indigenous rituals. In fact, San Pedro usage was not mentioned as a mind-altering plant by any healer or midwife interviewed and was not used in curing ceremonies. Centuries of prohibition have led to a pronounced abandonment of traditional knowledge. This is also reflected in the current study. Many plants used for magical purposes in Peru [125] have disappeared from traditional use in Ecuador. The fear of prosecution is still very deeply rooted in the healer community, and most healers interviewed stated that they did not wish to be cited by name.
Here are just a few studies which show carvacrols antibacterial capabilities:
Here are just a few reasons why using oregano oil over pharmaceutical antibiotics can be a good choice:
It enhanced the proliferation of spleen lymphocytes and interleukin-2 (IL-2) secretion and promoted phagocytosis and nitric oxide production in macrophages [116]. In a historical moment where anticancer research is headed towards immunotherapy, this finding is of great interest. Two hundred twenty-five extracts came from plant species that are traditionally employed against bacterial infections. One hundred sixty-six (73. 8) of these were active against at least one bacterium. Of the three hundred extracts from plants without traditional antibacterial use, only 96 (32) showed any activity. This shows clearly that plants traditionally used as antibacterial had a much higher likelihood to be antibacterially active than plants without traditional anti-bacterial use. However, the efficacy of plants used traditionally for antibacterial related applications did vary, which underlines the need for studies aiming to clearly understand traditional disease concepts. Plants used for respiratory disorders, inflammation/infection, wounds, and diarrhea, and to prevent postpartum infections, were efficacious in 7088 of the tests.
This could either be a relatively simple spraying with perfumes and holy water or an allnight ceremony involving the healers curing altar (mesa). In the days after an all-night ceremony, patients are normally treated with a baño de florecimiento (flowering bath) in order to relieve them of any remaining adversary symptoms or spirits. In addition, patients frequently receive seguros (herbal amulets) for protection against further evil influences and for good luck. Seguros are flasks filled with powerful herbs, as well as perfumes, pictures of saints, and the hair and fingernails of the patient. Objectives of the Centro up to 1992 were (1) Advance a health system favoring the majority of the community where Natural-Popular Medicine and modern medicine are complementary. (2) By means of study and application of Natural-Popular Medicine, create a scientific basis for its development. Revised objectives since 1992 are (1) Valorize and rescue Andean Medicine in order to contribute to better utilization and recognition within a system of alternative health available to a majority of the population. (2) Investigate, experiment, and disseminate the experiences and knowledge of Andean Medicine.
Most healing altars or mesas in Southern Ecuador are almost entirely devoid of any pagan objects such as seashells pre-Columbian ceramics. Patients are cleansed, by spraying them with holy water and perfumes. In rare cases tobacco juice and extracts of Jimson weed (Datura ferox) are used to purify the patients. Southern Ecuadorian mesas are also much less elaborated than the mesas of Peruvian curanderos. The incantations used by healers during their curing session center on Christian symbolism. References to Andean cosmology are almost entirely absent, and the use of guinea pigs as diagnostic instruments has all but disappeared from the tool kit of these healers. These illness categories are deeply rooted in Andean society, and Western medicine does not offer efficient alternatives to traditional treatment. This might explain why this category has still such an outstanding importance. Treatment in many cases involved the participation of the patient in a cleansing ceremony or limpia.
For this very reason, the American Food and Drug Administration (FDA) acknowledges natural products, the so-called botanical drugs, as therapeutic agents composed by vegetable materials, which may include plant materials, algae, macroscopic fungi, or combinations thereof. They are presented as products that are marketed as diagnosing, mitigating, treating, or curing a disease, and are thus deemed to be on an equal footing with traditional drugs in terms of activity and prescription regulations [13]. To date, two botanical drugs have been approved for marketing as prescription drugs, and several others as over-the-counter drugs, underlining the efficacy of this new category of therapeutic agents [13]. You dont have to stop taking it. I get that same issue sometimes. I take it every day. You should try using Oil of Oregano not Oregano Oil. The difference between them; oil of oregano is just diluted oregano oil. Or you can dilute your own oregano oil with a carrier oil like extra virgin olive oil. Dilute to 3 Parts carrier oil to one part oregano oil.
Even though carvacrol is among the most toxic for the mosquito, there is a great deal more research on 1,8-cineole from eucalyptus, which has been proven to be an effective natural mosquito repellent that rivals DEET in many ways. (19)Source: https://www.ncbi.nlm.nih.gov